TABLE 1.
Mice matings set-up to generate the different litters studied
| Litter notation | Male type | Female type | Number | Sacrificed at postnatal (P) day | Expected genotype of F1 generation | Observed phenotype |
|---|---|---|---|---|---|---|
| A1 | TectaA349D/A349D | TectaA349D/A349D | 8 | P16 | TectaA349D/A349D | Detached TM |
| A2 | TectaA349D/A349D | TectaA349D/A349D | 8 | P24 | TectaA349D/A349D | Detached TM |
| B | TectaA349D/A349D | 129SvEv+/+ | 17 | – | Tecta+/A349D | Not examined |
| C | TectaA349D/A349D | C57BL6J+/+ | nr | – | Tecta+/A349D | Not examined |
| D | TectaA349D/A349D | Tectb−/− | 8 | P13 | Tecta+/A349D, Tectb+/− | Attached TM |
| F |  |
Tectb−/− | 4 | P12 |  |
Attached TM |
| G | TectaY1870C/Y1870C | TectaA349D/A349D | 7 | P11 | TectaY1870C/A349D | Detached TM |
| I | TectaY1870C/Y1870C | Tectb−/− | 7 | P11 | TectaY1870C/+, Tectb+/− | Reduced limbal zone |
| J | TectaA349D/A349D |  |
10 | P13 | TectaΔENT/ΔENT | Detached TM |
| P | TectaY1870C/Y1870C |  |
8 | P12 |  |
Detached TM |
| U | TectaΔENT/ΔENT |  |
7 | P13 |  |
Detached TM |
| F2 of litter B: Q and R | Tecta+/A349D | Tecta+/A349D | 19 | P14 | 25% TectaA349D/A349D | Detached TM |
| 25% Tecta+/+ | Attached TM | |||||
| 50% Tecta+/A349D | Attached TM | |||||
| F2 of litter C: S and T | Tecta+/A349D | Tecta+/A349D | 29 | P15 | 25% TectaA349D/A349D | Detached TM |
| 25% Tecta+/+ | Attached TM | |||||
| 50% Tecta+/A349D | Attached TM |
TM Tectorial membrane, nr not recorded