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Quantitative analysis of hair cell damage due to gentamicin combined with the PKC inhibitor, calphostin C. Gentamicin alone (35 μM) induced outer hair cell damage of about 30%. Calphostin C with gentamicin enhanced hair cell damage significantly at 50 and 100 nM (p < 0.05), but not at 10 nM. Calphostin C alone at 100 nM had no effect on hair cells.
