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Onset adaptation of distortion product otoacoustic emissions (DPOAEs) was not reliably changed by MPTP treatment. DPOAEs show a rapid level-dependant adaptation shortly after signal onset when the medial olivocochlear (MOC) pathway is intact. DPOAE adaptation is depicted 30 min after sequential applications of artificial perilymph (panels A, B, C), 30 min after applying 50 mM MPTP to the round window membrane (D), and after i.v. strychnine (0.15 mg/kg, see panel E).
