Table 1.
Level | Year of study | Study | Journal | Group 1 | Group 2 | Total enrolled participants | Mean patient age (years) | Method of randomization | Percent traumatic | Duration of symptoms (months) | Lesion size (cm2)* | Lesion location |
---|---|---|---|---|---|---|---|---|---|---|---|---|
I | 2005 | Gudas et al. [19] | Arthroscopy | OAT arthroscopic | Microfracture | 60 | 24.3 | Envelope | 56% | 21.3 | 2.8 (1–4) | 84% MFC |
16% LFC | ||||||||||||
I | 2005 | Bartlett et al. [1] | JBJS Br | ACI-C | MACI (3D) | 91 (112)† | 33.5 | Block randomization | 43% | 102.7 | 6.1 (1–22) | 45% MFC |
10% LFC | ||||||||||||
32% Patella | ||||||||||||
13% Trochlea | ||||||||||||
I | 2004 | Knutsen et al. [29] | JBJS Am | ACI-P | Microfracture | 80 | 32.2 | Envelope | 65% | 36 | 4.8 (2–10) | 89% MFC |
11% LFC | ||||||||||||
I | 2004 | Visna et al. [45] | ACB | MACI (3D) | Abrasion | 50 (60)† | 30.8 | Envelope | 86% | NR | 3.72 (2–10) | 55% MFC |
18% LFC | ||||||||||||
18% Patella | ||||||||||||
8% Tibial plateau | ||||||||||||
I | 2003 | Bentley et al. [2] | JBJS Br | ACI-P: 6 ACI-C: 46 | OAT open | 100 | 31.3 | Random number | 46% | 86.4 | 4.66 (1–12.2) | 53% MFC |
18% LFC | ||||||||||||
25% Patella | ||||||||||||
1% Tibial plateau | ||||||||||||
3% Trochlea | ||||||||||||
II | 2003 | Horas et al. [24] | JBJS Am | ACI-P | OAT open | 40 | 33.4 | Alternating | 100% | NR | 3.75 (3.2–5.6) | 82% MFC |
18% LFC |
*Values expressed as mean, with range in parentheses; †number of lesions in parentheses; multiple lesions addressed in some knees; OAT = osteochondral autograft transplant; MFC = medial femoral condyle; LFC = lateral femoral condyle; JBJS Br = Journal of Bone and Joint Surgery–British Edition; MACI = matrix-induced autologous chondrocyte implantation; ACI-C = autologous chondrocyte implantation–collagen cover; JBJS Am = Journal of Bone and Joint Surgery–American Edition; ACI-P = autologous chondrocyte implantation–periosteal patch; ACB = Acta Chirurgica Belgica; 3D = three dimensional; NR = not reported.