Table 1.

Selected demographic data from included studies

Level	Year of study	Study	Journal	Group 1	Group 2	Total enrolled participants	Mean patient age (years)	Method of randomization	Percent traumatic	Duration of symptoms (months)	Lesion size (cm2)*	Lesion location
I	2005	Gudas et al. [19]	Arthroscopy	OAT arthroscopic	Microfracture	60	24.3	Envelope	56%	21.3	2.8 (1–4)	84% MFC
												16% LFC
I	2005	Bartlett et al. [1]	JBJS Br	ACI-C	MACI (3D)	91 (112)†	33.5	Block randomization	43%	102.7	6.1 (1–22)	45% MFC
												10% LFC
												32% Patella
												13% Trochlea
I	2004	Knutsen et al. [29]	JBJS Am	ACI-P	Microfracture	80	32.2	Envelope	65%	36	4.8 (2–10)	89% MFC
												11% LFC
I	2004	Visna et al. [45]	ACB	MACI (3D)	Abrasion	50 (60)†	30.8	Envelope	86%	NR	3.72 (2–10)	55% MFC
												18% LFC
												18% Patella
												8% Tibial plateau
I	2003	Bentley et al. [2]	JBJS Br	ACI-P: 6 ACI-C: 46	OAT open	100	31.3	Random number	46%	86.4	4.66 (1–12.2)	53% MFC
												18% LFC
												25% Patella
												1% Tibial plateau
												3% Trochlea
II	2003	Horas et al. [24]	JBJS Am	ACI-P	OAT open	40	33.4	Alternating	100%	NR	3.75 (3.2–5.6)	82% MFC
												18% LFC

*Values expressed as mean, with range in parentheses; ^†number of lesions in parentheses; multiple lesions addressed in some knees; OAT = osteochondral autograft transplant; MFC = medial femoral condyle; LFC = lateral femoral condyle; JBJS Br = Journal of Bone and Joint Surgery–British Edition; MACI = matrix-induced autologous chondrocyte implantation; ACI-C = autologous chondrocyte implantation–collagen cover; JBJS Am = Journal of Bone and Joint Surgery–American Edition; ACI-P = autologous chondrocyte implantation–periosteal patch; ACB = Acta Chirurgica Belgica; 3D = three dimensional; NR = not reported.