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The effect of NBD-556 on viral entry. The effect of NBD-556 on the infection of Cf2Th-CCR5 cells by recombinant luciferase-expressing HIV-1 bearing the envelope glycoproteins of the YU2 strain of HIV-1 or the amphotropic murine leukemia virus (A-MLV) is shown. Virus infection is expressed as the percentage of infection (measured by luciferase activity in the target cells) observed in the presence of NBD-556 relative to the level of infection observed in the absence of drug.
