Table 1.
Anti-TB activities, cytotoxicity (IC50) and selectivity indices (SIs) of extract partitions and the isolated polyynes 1-5 from A. sinensis
| Extract/compounds | MICa,b(μg/mL) | Cytotoxicity IC50 (μg/mL) | SIc | ||
|---|---|---|---|---|---|
| Erdman | H37Rv | Erdman | H37Rv | ||
| MeOH extract | >128 | 85.1 | |||
| PE extract | >128 | 64.0 | |||
| CHCl3 extract | 124.6 | 63.1 | |||
| BuOH extract | >128 | >128 | |||
| H2O extract | >128 | >128 | |||
| 1 | 6.0 | 26.7 | >120 | >19 | >4 |
| 2 | 1.4 | 25.3 | >120 | >117 | >4 |
| 3 | 49.5 | 50.2 | >120 | >2 | >2 |
| 4 | >60 | >60 | >120 | n/a | n/a |
| 5 | >60 | >60 | >120 | n/a | n/a |
| RMPd | 0.05 | 0.06 | 111.6 | 2232 | 1860 |
a
Minimum inhibitory concentration defined as the concentration at which the samples exhibit an inhibition of ≥ 90% in the MABA assay.
b
Average ± SD of triplicate determinations.
c
Selectivity index (SI = IC50/MIC).
d
Positive control (Rifampin); negative control was solvent (DMSO).
n/a = not applicable.