Table 1.
Time in months at which tumor progression was noted by clinical criteria (CLIN), volumetrics (VOL), and by vessel malignancy probability (MP). Subjects are classified into 5 response groups (column 1), with the patient identification number given in column 2. Column 5 provides comments, with “CM” indicating carcinomatous meningitis and “Volume smaller?” indicating a volumetric decrease insufficient to meet formal criteria for volumetric reduction.
| Group | Study ID | CLIN | VOL | MP | COMMENT |
|---|---|---|---|---|---|
| 1 | 007 | 2 | 2 | 2 | Failed by all criteria |
| 1 | 009 | 2 | 2 | 2 | Failed by all criteria |
| 1 | 016 | 2 | 2 | 2 | Failed by all criteria |
| 1 | 022 | 2 | 2 | 2 | Failed by all criteria |
| 2 | 006 | 4 | 2 | 2 | Monotonic 3D tumor growth |
| 2 | 010 | 6 | 2 | 2 | Monotonic 3D tumor growth |
| 2 | 026 | 4 | 2 | 2 | Monotonic 3D tumor growth |
| 2 | 029 | 4 | 2 | 2 | Monotonic 3D tumor growth |
| 3 | 008 | 4 | 4 | 2 | Slow, monotonic tumor growth |
| 3 | 012 | 7 | 6 | 2 | Volume smaller? month 2 only |
| 3 | 015 | 6 | 4 | 2 | Volume smaller month 2 only |
| 3 | 023 | 4 | 4 | 2 | Volume smaller? month 2 only |
| 3 | 027 | 3 | 3 | 2 | Volume smaller? month 2 only |
| 4 | 018 | 4 | >4 | 2 | Only tiny lesions |
| 5 | 003 | 11 | >10 | 4 | Volume smaller; new CM |
| 5 | 013 | 6 | >6 | 6 | Lesion stable after month 2 |