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. 2008 Apr 24;84(1):302–310. doi: 10.1189/jlb.0208090

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/us/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 5. — MDA-MB-231 human Nrp1⁺ breast cancer cells bind and activate latent TGF-β1. (A) Incubation of the cells with LAP-TGF-β1 and fluorescent LAP staining showing retention of LAP. (B) Cells treated with anti-Nrp1 mAb-blocking antibody and LAP-TGF-β1 and stained for LAP. (C) p-Smad2 fluorescent staining of untreated cultured cells. (D) p-Smad2 staining of cells incubated with LAP-TGF-β1. (E) p-Smad2 staining of cells incubated with anti-Nrp1 antibody and LAP-TGF-β1. (F) p-Smad2 staining of cells incubated with SD-208 and LAP-TGF-β1. The results of A–F are representative of three separate experiments.