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. 2007 Aug 10;148(1-5):7–21. doi: 10.1016/j.neuroscience.2007.06.002

Fig. 1.

Fig. 1

ACPT-1 differentially modulates sEPSCs and eEPSCs. (A) Voltage clamp recording from a layer V neurone illustrating the increase in sEPSCs elicited by ACPT-1. (B) Cumulative probability analysis of interevent interval of sEPSCs in pooled data (n=10). The shift to the left of the distribution in ACPT-1 reflects the increase in frequency compared with control (c). (C) Pooled data of cumulative probability analysis of mEPSCs showing the persistence of the increase in frequency with no significant change in amplitude (n=7). (D) eEPSCs (five events superimposed) recorded in the same neurone shown in A, illustrating the concurrent reduction of AP-dependent-release. (E) Summary data for eEPSC changes in the same set of neurones as in B, showing the consistent reduction in eEPSCs concurrent with the increased frequency of sEPSCs. Scale bars=15 pA, 500 ms (A); 30 pA, 30 ms (D).