Fig. 2.

Blockade of mGluRs with CPPG reveals tonic effects on eEPSCs but not sEPSCs. (A) sEPSCs recorded from a layer V neurone showing little effect of CPPG (2 μM). (B) The cumulative probability plot of pooled data from eight neurones shows a slight shift toward shorter intervals but this was not significant, indicating no change in frequency. (C) The traces are averaged records (n=6) of eEPSCs evoked at 20 Hz. CPPG enhanced the amplitude of early events in the train. (D) The bar chart shows pooled data from eight cells in which mean eEPSC amplitude was measured during the train. The amplitude of the first three eEPSCs in a train was significantly enhanced, but the later events were unaffected. Scale bars=15 pA, 100 ms (A); 20 pA, 30 ms (C).