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. Author manuscript; available in PMC: 2009 May 27.
Published in final edited form as: Biochemistry. 2008 May 6;47(21):5774–5783. doi: 10.1021/bi800205t

Figure 1. The HS structure and the preparation of 3-O-sulfated octasaccharide by 3-OST-3.

Figure 1

Panel A shows the structures of the disaccharide building blocks that make up heparin and heparan sulfate. Numbers represents positions. Panel B illustrates the scheme to prepare 3-O-sulfated octasaccharide using 3-OST-3 enzyme. For clarity, each sugar unit of the octasaccharide is labeled as U1, G2, etc, where U is uronic acid, G is glucosamine, and I is iduronic acid. Also, R can be either H or SO3H while R′ can be either H, Ac, or SO3H where Ac is an acetyl group.