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. 2008 Aug 15;283(33):22601–22611. doi: 10.1074/jbc.M800524200

FIGURE 4.

FIGURE 4.

Cannabinoids WIN55,212-2 and CP55,940 fail to prevent LPS-induced elevation of hippocampal COX-2. a1, immunoblot analysis of COX-2 expression in hippocampi from mice treated with vehicle, LPS, LPS + WIN, or LPS + CP. WIN and CP were injected 30 min before LPS injection. COX-2 protein was detected 4 h after the injections. a2, quantifications of COX-2 expressions under different treatments (n = 3). **, p < 0.01 compared with vehicle controls. b1, immunoblot analysis of COX-2 expression in hippocampi from mice treated with vehicle, LPS, LPS + 2-arachidonyl glycerol ether (2-AGE), or LPS + AA. 2-Arachidonyl glycerol ether and AA were injected 30 min before LPS injection. COX-2 protein was detected 4 h after injections. b2, quantifications of COX-2 expressions under different treatments (n = 3). **, p < 0.01 compared with vehicle controls; ##, p < 0.01 compared with LPS.