Cannabinoids WIN55,212-2 and CP55,940 fail to prevent LPS-induced
elevation of hippocampal COX-2. a1, immunoblot analysis of COX-2
expression in hippocampi from mice treated with vehicle, LPS, LPS + WIN, or
LPS + CP. WIN and CP were injected 30 min before LPS injection. COX-2 protein
was detected 4 h after the injections. a2, quantifications of COX-2
expressions under different treatments (n = 3). **,
p < 0.01 compared with vehicle controls. b1, immunoblot
analysis of COX-2 expression in hippocampi from mice treated with vehicle,
LPS, LPS + 2-arachidonyl glycerol ether (2-AGE), or LPS + AA.
2-Arachidonyl glycerol ether and AA were injected 30 min before LPS injection.
COX-2 protein was detected 4 h after injections. b2, quantifications
of COX-2 expressions under different treatments (n = 3).
**, p < 0.01 compared with vehicle controls; ##,
p < 0.01 compared with LPS.