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. 2008 Aug 15;283(33):22601–22611. doi: 10.1074/jbc.M800524200

FIGURE 6.

FIGURE 6.

ERK, MAPK, phosphoinositide 3-kinase, and NF-κB signaling pathways are involved in the 2-AG-induced suppression of COX-2 elevation. a1, Western immunoblot analysis of phosphorylation of p38 MAPK in hippocampal tissue from mice that received vehicle, LPS, LPS + 2-AG, and LPS + 2-AG + SR-1. a2, quantifications of p38 MAPK phosphorylation. b1, immunoblot analysis of NF-κB phosphorylation in the mouse hippocampus. b2, quantifications of NF-κB phosphorylation (n = 3). **, p < 0.01 compared with vehicle controls; ##, p < 0.01 compared with LPS. c1, Western blot analysis of ERK1/2 and Akt phosphorylation in hippocampal tissue from mice injected with vehicle, LPS, and LPS + 2-AG. c2 and c3, quantifications of ERK1/2 and Akt phosphorylation. **, p < 0.01 compared with vehicle controls; ##, p < 0.01 compared with LPS (n = 3). d1, Western blot analysis of ERK1/2 and Akt phosphorylation in hippocampal tissue from mice injected with vehicle, KA, KA + 2-AG, and KA + 2-AG + SR-1. c2 and c3, quantifications of ERK1/2 and Akt phosphorylation. **, p < 0.01 compared with vehicle controls; ##, p < 0.01 compared with KA (n = 3).