TABLE 1.
KCNQ1a | ZnPy (5 μm)a | KCNQ1-KCNE1a | KCNQ1-KCNE3b | |
---|---|---|---|---|
G/G0 | 1.0 | 4.2 ± 0.8c | 4.3 ± 0.9c | 4.4 ± 1.5c |
τ activation (ms) | 23.4 ± 4.9 | 73.7 ± 12.5c | τ1, 1297.6 ± 432.5c; τ2, 218.0 ± 46.8 | 25.9 ± 2.8 |
τ deactivation (ms) | 60.6 ± 6.2 | 113.20 ± 15.41c | 243.8 ± 47.9c | 21.6 ± 3.4c |
Inactivation (%) | 67.2 ± 3.7 | 14.2 ± 12.5c | NA | NA |
The KCNQ1 and KCNQ1-KCNE1 currents were elicited by depolarization to +50 mV
The KCNQ1-KCNE3 currents were elicited by depolarization to +40 mV
*, p < 0.05 compared with KCNQ1