Skip to main content
. 2008 Aug 15;283(33):22464–22472. doi: 10.1074/jbc.M800842200

FIGURE 4.

FIGURE 4.

PGC-1α modulates mitochondrial biology and insulin signaling. A shows murine PGC-1α promoter activation in response to pioglitazone (cont, control; Pio, pioglitazone). B, infection of PGC-1α up-regulates PGC-1α and COX I protein levels. MOI, multiplicity of infection. C, augmentation of relative rate of oxygen consumption in cells with increasing levels of PGC-1α and the relative O2 consumption comparing GFP to PGC-1α vector at a multiplicity of infection of 100. D shows the restoration of insulin-mediated signaling (% GFP/cont without insulin) by PGC-1α overexpression (pTyr, phosphotyrosine; cont, control). E, induction of oxygen consumption by PGC1α overexpression in, insulin resistance myotubes. F, effect of PGC-1α silencing on transcript levels and on oxygen consumption (% si cont); G, the diminution of Akt threonine phosphorylation by insulin after partial silencing of PGC-1α.