Cell surface association of soluble HBD2. A, HBD2-specific
ELISA analysis of medium supernatant and cell lysate collected from
RSV-infected (0–16 h post-infection) A549 cells. B,
HBD2-specific ELISA analysis of medium supernatant and cell lysate collected
from TNF-treated (0–16 h treatment) A549 cells. C, medium
supernatant and cell lysate collected from A549 cells incubated with 1 μg
of purified HBD2 for 0–16 h were subjected to ELISA to detect
cell-associated versus soluble HBD2. Amount of HBD2 deduced from the
ELISA was expressed as ng/ml, and each value represents the mean ± S.D.
for three determinations. D, A549 cells incubated with 1 μg of
purified HBD2 for 0–24 h were biotinylated (cell surface biotinylation),
followed by precipitation with avidin-agarose and blotting with anti-HBD2
antibody.