Table 2.
Age adjusted association (odds ratio)* between migraine and Framingham predicted 10 year risk of coronary heart disease in 27 519 women in women’s health study
| Framingham estimate of 10 year risk of coronary heart disease | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No of women in category ≤1% | 2-4% | 5-9% | ≥10% | |||||||||
| No of women | OR (95% CI) | P value | No of women | OR (95% CI) | P value | No of women | OR (95% CI) | P value | ||||
| No history of migraine (n=22 445) | 12 000 | 6912 | 1.00 (reference) | — | 2632 | 1.00 (reference) | — | 901 | 1.00 (reference) | — | ||
| History of migraine: | ||||||||||||
| Any (n=5074) | 2862 | 1487 | 1.09 (1.01 to 1.17) | 0.03 | 535 | 1.15 (1.03 to 1.29) | 0.02 | 190 | 1.26 (1.06 to 1.49) | 0.009 | ||
| Active migraine with aura (n=1418) | 840 | 393 | 1.02 (0.89 to 1.17) | 0.76 | 141 | 1.14 (0.94 to 1.40) | 0.19 | 44 | 1.14 (0.82 to 1.59) | 0.42 | ||
| Active migraine without aura (n=2159) | 1332 | 595 | 1.02 (0.92 to 1.14) | 0.72 | 178 | 1.00 (0.84 to 1.20) | 0.97 | 54 | 1.02 (0.76 to 1.36) | 0.92 | ||
| Prior migraine† (n=1497) | 690 | 499 | 1.27 (1.12 to 1.45) | <0.01 | 216 | 1.46 (1.22 to 1.75) | <0.01 | 92 | 1.83 (1.43 to 2.35) | <0.01 | ||
*Calculated from multinominal logistic regression model with women without history of migraine and with Framingham estimated 10 year risk of coronary heart disease ≤1% as reference group.
†Women with history of migraine but no active migraine in year before completing baseline questionnaire.