Table 4.
Age adjusted association (hazard ratio) between migraine and ischaemic stroke, stratified by components of Framingham risk score in 27 519 women in women’s health study
| No history of migraine (n=22 445)* | Active migraine with aura (n=1418) | Active migraine without aura (n=2159) | Previous migraine† (n=1497) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No of women | HR (95% CI) | P value | No of women | HR (95% CI) | P value | No of women | HR (95% CI) | P value | |||||
| Age (years): | |||||||||||||
| 45-54 (n=16 444) | 64 | 12 | 2.59 (1.40 to 4.80) | 0.003 | 8 | 1.07 (0.51 to 2.24) | 0.85 | 2 | 0.51 (0.12 to 2.07) | 0.34 | |||
| 55-64 (n=8160) | 91 | 9 | 2.13 (1.07 to 4.23) | 0.03 | 5 | 0.79 (0.32 to 1.95) | 0.61 | 8 | 1.19 (0.58 to 2.46) | 0.63 | |||
| ≥65 (n=2915) | 96 | 1 | 0.32 (0.04 to 2.29) | 0.26 | 4 | 1.28 (0.47 to 3.49) | 0.63 | 6 | 0.85 (0.37 to 1.93) | 0.69 | |||
| Systolic blood pressure (mm Hg): | |||||||||||||
| <120 (n=12 389) | 55 | 10 | 3.42 (1.74 to 6.75) | <0.001 | 3 | 0.69 (0.22 to 2.22) | 0.54 | 4 | 1.21 (0.44 to 3.34) | 0.71 | |||
| 120-139 (n=11 678) | 102 | 6 | 1.18 (0.52 to 2.69) | 0.69 | 10 | 1.47 (0.76 to 2.84) | 0.25 | 7 | 0.93 (0.43 to 2.00) | 0.85 | |||
| ≥140 (n=3452) | 94 | 6 | 1.49 (0.65 to 3.42) | 0.34 | 4 | 0.65 (0.24 to 1.77) | 0.40 | 5 | 0.67 (0.27 to 1.65) | 0.39 | |||
| Smoking: | |||||||||||||
| Never (n=14 219) | 104 | 11 | 2.31 (1.23 to 4.32) | 0.009 | 8 | 1.12 (0.54 to 2.32) | 0.76 | 4 | 0.54 (0.20 to 1.45) | 0.22 | |||
| Past (n=10 100) | 98 | 6 | 1.23 (0.54 to 2.82) | 0.62 | 5 | 0.82 (0.33 to 2.03) | 0.67 | 6 | 0.89 (0.39 to 2.04) | 0.79 | |||
| Current (n=3200) | 49 | 5 | 2.10 (0.84 to 5.30) | 0.11 | 4 | 1.25 (0.45 to 3.47) | 0.67 | 6 | 1.63 (0.70 to 3.81) | 0.26 | |||
| Total cholesterol (mmol/l): | |||||||||||||
| <5.17 (n=11 171) | 58 | 10 | 3.29 (1.68 to 6.45) | <0.001 | 9 | 2.18 (1.07 to 4.44) | 0.03 | 7 | 1.85 (0.84 to 4.05) | 0.12 | |||
| 5.17-6.20 (n=10 292) | 106 | 5 | 1.08 (0.44 to 2.65) | 0.87 | 4 | 0.58 (0.21 to 1.58) | 0.29 | 4 | 0.58 (0.21 to 1.57) | 0.28 | |||
| ≥6.21 (n=6056) | 87 | 7 | 1.56 (0.72 to 3.38) | 0.26 | 4 | 0.65 (0.24 to 1.77) | 0.39 | 5 | 0.69 (0.28 to 1.70) | 0.42 | |||
| HDL cholesterol (mmol/l): | |||||||||||||
| <1.03 (4762) | 60 | 5 | 1.56 (0.63 to 3.90) | 0.34 | 7 | 1.55 (0.70 to 3.42) | 0.28 | 6 | 1.33 (0.57 to 3.07) | 0.51 | |||
| 1.03-1.54 (n=14 536) | 121 | 13 | 2.19 (1.23 to 3.89) | 0.008 | 5 | 0.61 (0.25 to 1.49) | 0.28 | 7 | 0.81 (0.38 to 1.74) | 0.60 | |||
| ≥1.55 (n=8221) | 70 | 4 | 1.27 (0.46 to 3.48) | 0.64 | 5 | 1.12 (0.45 to 2.79) | 0.81 | 3 | 0.61 (0.19 to 1.95) | 0.41 | |||
HDL=high density lipoprotein.
*Hazard ratio=1.
†History of migraine but no active migraine in year before completion of baseline questionnaire.