. Author manuscript; available in PMC: 2008 Aug 11.

Published in final edited form as: J Med Chem. 2006 Jun 1;49(11):3368–3376. doi: 10.1021/jm060142p

Table 1.

Response of Jurkat cells and the NCI tumor cell panel to prodrugs. NFAT assay, cells exposed to drug for 6 hr; NCI panel, cells exposed to drug for 48 hr. See Experimental section for details.

Cpd	NFAT IC₅₀, μM^a	NCI Panel GI₅₀, μM^b
8	31 ± 3	12 ± 7
9	9 ± 5	3 ± 1
10	21 ± 4	6 ± 5
16	16 ± 5	18 ± 10
17	20 ± 4	N.D.^c
18	28 ± 3	N.D.

Mean ± S.E., n = 4.

Mean ± S.D. for 62 cell lines in the panel.

Not determined.