Figure 4.

Effects of pretraining injection of the 11β-hydroxylase inhibitor metyrapone (35 mg/kg, s.c.) and immediate post-training injections of corticosterone (1.0 or 3.0 mg/kg, s.c.) on taste aversion as assessed on a 96-h retention test trial. (A) Experimental design. (B) Metyrapone (Mety) impaired CTA retention, an effect that was dose-dependently reversed by corticosterone. The aversion index (mean ± SEM) is expressed as the percent saccharin consumption on the retention test as compared with that during acquisition. (^◆◆) P < 0.01 as compared with the vehicle (Veh) group; (*) P < 0.05 as compared with the Mety + Veh group (n = 15–16 rats per group).