Figure 4.

LTP in the dentate gyrus of awake freely-moving WT and Tc1 mice. The graph plots the time course of LTP induced at MPP-granule cell synapses in freely-moving animals (WT: open circles, n = 8; Tc1: filled circles, n = 9). Baseline responses were recorded for 2 d (30 min per day). A tetanus (six series of six trains of six stimuli at 400 Hz, 200 msec between trains, 20 sec between series) was delivered (arrow) on the second day, and responses were monitored for 1 h, and again for 30 min per day for the next 2 d. Each data point presented is an average of ten successive sampled responses over 5 min. The horizontal line represents percentage of baseline. Tc1 mice showed reduced LTP after the delivery of the tetanus, but normal maintenance at days 3 and 4. Values represent means ± SEM.