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. 2008 Jun 5;22(8):1767–1780. doi: 10.1210/me.2007-0574

Figure 4.

Figure 4

UV-Induced uPA Expression Is Repressed by GR

A, NIH-3T3 cells were either treated with TPA or UV irradiated in the presence or absence of dexamethasone (Dex). Total RNA was prepared and subjected to Northern blotting using probes specific for uPA, collagenase I (Coll), or GAPDH. B, HeLa cells were cotransfected with the −1977/−1858uPA-TATA-luciferase reporter gene and Ubi-Renilla and either treated with TPA or UV irradiated in the presence or absence of dexamethasone (Dex). Luciferase activities normalized to Renilla activities are plotted as fold induction (mean ± sd of one representative experiment performed in triplicates).