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Kinetics of the CTL response in DNA-immunized mice. Splenocytes from BALB/c × C57BL/6 mice were taken 2 or 8 weeks postimmunization with CIGH-OVA, restimulated in vitro for 5 days, and tested for their ability to lyse EG7 (solid symbols) or control EL4 (open symbols) in a standard 51Cr release assay. Results shown are from two representative animals at each time point. No specific lysis of EG7 or EL4 cells was seen with naive control animals.
