Table 4.

Piecewise exponential hazard regression model for factors associated with death in cases aged 18–64 years with invasive pneumococcal infection

	Death at 0–7 days			Death at 8–28 days			Death at 29–90 days
Factor	Hazard ratio	95%CIa	P-value	Hazard ratio	95%CIa	P-value	Hazard ratio	95%CIa	P-value
Male sex	0.9	0.6–1.2	0.5	1.6	1.3–2.0	< 0.001	1.6	1.3–2.0	< 0.001
Age > 50 years	1.3	1.1–1.7	< 0.05	1.3	1.1–1.7	< 0.05	2.8	2.2–3.5	< 0.001
Meningitis	1.2	0.7–2.3	0.7	3.2	2.0–5.0	< 0.001	0.7	0.4–1.2	0.3
Alcohol-related diseases	5.6	3.8–8.1	< 0.001	3.8	2.9–4.9	< 0.001	3.8	2.9–4.9	< 0.001
Cardiac failure	2.6	1.8–3.8	< 0.001	2.6	1.8–3.8	< 0.001	2.6	1.8–3.8	< 0.001
Chronic renal failure	1.6	0.5–5.2	0.4	1.6	0.5–5.2	0.4	1.6	0.5–5.2	0.4
Chronic liver disease	4.4	2.3–8.6	< 0.001	4.4	2.3–8.6	< 0.001	4.4	2.3–8.6	< 0.001
HIV infection	4.8	2.1–10.9	< 0.001	4.8	2.1–10.9	< 0.001	4.8	2.1–10.9	< 0.001
Haematological malignancyb	0.9	0.2–3.5	0.6	0.9	0.2–3.5	0.6	6.9	4.1–11.5	< 0.001
Non-haematological malignancyb	4.7	3.3–6.7	< 0.001	4.7	3.3–6.7	< 0.001	4.7	3.3–6.7	< 0.001
Diabetes mellitus	1.4	0.9–2.0	0.13	1.4	0.9–2.0	0.13	1.4	0.9–2.0	0.13
Chronic pulmonary disease	1.0	0.6–1.6	1.0	1.0	0.6–1.6	1.0	1.0	0.6–1.6	1.0
Organ/bone marrow transplantation	0.9	0.4–1.8	0.7	0.9	0.4–1.8	0.7	0.9	0.4–1.8	0.7
Immunodeficiency/rheumatic diseases	1.7	1.2–2.2	< 0.05	1.7	1.2–2.2	< 0.05	1.7	1.2–2.2	< 0.05
Otherc medical underlying conditions	1.7	1.3–2.2	< 0.001	1.7	1.3–2.2	< 0.001	1.7	1.3–2.2	< 0.001
Healthy	Ref.d			Ref.			Ref.

^aCI, confidence interval; ^b < 1 year since cancer diagnosis; ^cnon-PPV23 indication; ^dRef., reference