Table 5. Associations of C-reactive Protein (CRP) with Carotid Intima-media Thickness (CIMT) Obtained from the Instrumental Variables Analysis in Which CRP Haplotypes Act as An Instrument for the Non-confounded and Unbiased Effect of CRP.

Exposure	N	Age and Sex Adjusted Beta (95% CI) for CIMT (mm) at Mean Age of 61.0 Years
Per doubling of CRP concentration at mean age 61.0	3299	−0.005 (−0.031 to 0.021) P = 0.71
Per doubling of CRP concentration at mean age 49.2	3016	−0.001 (−0.025 to 0.023) P = 0.94