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. 2008 Aug 29;4(8):e1000167. doi: 10.1371/journal.pcbi.1000167

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Tanouchi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) A minimal QS motif. AHL and LuxR are produced at constant rates inside the cell. AHL can diffuse across the cell membrane. At sufficiently high concentrations, the intracellular AHL binds to and activates LuxR. The active LuxR (the complex) further dimerizes and activates a downstream gene (X) controlled by the P_lux promoter. Many natural QS systems share this common motif. (B) Noise processing by QS. Noise sources can be considered as inputs to the system. A QS motif processes the noise sources and results in noise in C as an output.