Figure 3. Fast R decay reduces the extrinsic noise in the presence of fast signal diffusion.

(A) With diffusion (P = 2×10⁻¹³ L min⁻¹), faster R decay drastically reduces total noise (black line) by decreasing the extrinsic noise (blue line) without significantly affecting the intrinsic noise (red line). Without diffusion, faster R decay has little effect on either the intrinsic or the extrinsic noise (dotted lines). (B) Fast R decay significantly reduces the gain of low-frequency extrinsic noise components transmitted to the complex in the presence of diffusion. For these calculations, P = 2×10⁻¹³ L min⁻¹, γ_R = 0.02 min⁻¹ for slow R decay, and 2 min⁻¹ for fast R decay.