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. Author manuscript; available in PMC: 2008 Aug 12.
Published in final edited form as: Biochemistry. 2006 Jul 25;45(29):8988–8999. doi: 10.1021/bi0606602

Table 4.

Solvent Isotope Effects for M. tuberculosis IPMSa

Solvent Isotope Effects
Fixed Substrate Variable Substrate D2OV D2OV/K
Pyruvate AcCoA 2.0 ± 0.2 1
AcCoA Pyruvate 1.8 ± 0.2 2.2 ± 0.5
a

Solvent isotope effects were determined in 100% H2O or 80 % D2O, at pH 8.3 and 25°C.