Skip to main content
. Author manuscript; available in PMC: 2008 Aug 12.
Published in final edited form as: Curr Drug Metab. 2008 Jul;9(6):471–486. doi: 10.2174/138920008784892065

Fig. 1. Metabolism of arylamines includes both activation and inactivation via N-acetylation, O-acetylation, and N,O-acetylation catalyzed by NAT2.

Fig. 1

These reactions are depicted for the arylamine carcinogen 4-aminobiphenyl, ultimately leading to the generation of highly reactive electrophiles that bind to DNA potentially leading to mutations and cancer. Adapted from [5].