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. Author manuscript; available in PMC: 2008 Aug 12.
Published in final edited form as: Curr Drug Metab. 2008 Jul;9(6):471–486. doi: 10.2174/138920008784892065

Fig. 4. Effects of individual SNPs in NAT2 on the N-acetylation of sulfamethazine (SMZ) and 2-aminofluorene (AF) and the O-acetylation of N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (N-OH-MeIQx) and N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (N-OH-PhIP).

Fig. 4

Each bar represents Mean ±SEM for three determinations following recombinant expression in yeast (Schizosaccaromyces pombe). The effect of the SNPs on NAT2 catalytic activity are generally consistent across the substrates with the exception of A845C and G857A, which reduce activity towards AF and N-OH-MeIQx far more than they do towards SMZ and N-OH-PhIP. Ref: Reference allele (NAT2*4, no SNPs); ND; Non-detectable. Adapted from [23,26,55].