Figure 3.

Binding of human natural IgG antibodies and cytotoxicity of natural human antibodies on splenocytes from α-galactosidase transgenic mice. (A) FACS profiles of splenocytes from transgenic mice heterozygous for human α-galactosidase or nontransgenic littermates stained with human natural IgG antibodies. (B) Cytotoxicity of spleen cells from normal and α-galactosidase-transgenic mice. Vertical axis, % lysis; horizontal axis, doubling dilutions of human serum commencing at 1/2; RC’, rabbit complement. Results are representative of three experiments.