Figure 2.

Blood pressures, heart weights, and survivals of mutant and wild-type mice. (A) Blood pressures as a function of Npr1 genotype and dietary salt. Mean blood pressures measured by a noninvasive computerized tail-cuff method in conscious young adult mice aged 95–115 days are shown for male (n = 12 per genotype) and female (n = 20 per genotype) Npr1 −/− (solid bars) and +/+ (open bars) animals on a low (0.05% NaCl), intermediate (2% NaCl), or high (8% NaCl) salt diet. SEMs are indicated above the bars. ∗, P < 0.001 vs. wild-type controls by ANOVA. (B) Heart weights as a percent of total body weight of 3-month-old mice. Individual values are represented as squares (males) and circles (females), and mean values are indicated by horizontal lines. ∗, P < 0.001 and †, P < 0.01 vs. wild-type controls by two-tailed t test. (C) The percentage survival of male (M) and female (F) Npr1 −/− animals and wild-type (+/+) controls as a function of age.