Table 1.

Echocardiographic and chamber weight findings in Npr1-deficient mice

	Npr1 +/+ (n = 10)	Npr1 −/− (n = 4)
BW (g)	28.19 ± 0.69	29.62 ± 1.37
LVEDD (mm)	3.82 ± 0.08	4.89 ± 10†
LVESD (mm)	2.43 ± 0.11	3.06 ± 0.08*
PWth (mm)	0.66 ± 0.04	0.67 ± 0.03
IVSth (mm)	0.65 ± 0.04	0.66 ± 0.02
FS (%)	36.6 ± 1.9	37.3 ± 1.10
HR (bpm)	273 ± 21	253 ± 26
Vcf (circ/s)	5.19 ± 0.34	5.15 ± 0.27
HW/BW (mg/g)	4.55 ± 0.15	7.13 ± 32†
LV/BW (mg/g)	3.30 ± 0.11	4.89 ± 0.28†
RV/BW (mg/g)	1.00 ± 0.04	1.64 ± 0.16*
LA/BW (mg/g)	0.13 ± 0.01	0.32 ± 0.03†
RA/BW (mg/g)	0.13 ± 0.01	0.28 ± 0.01†

Data expressed as mean ± SE. BW, body weight; LVEDD, left ventricular end diastolic dimension; LVESD, left ventricular end systolic dimension; IVSth, interventricular septal wall thickness; PWth, posterior wall thickness; HR, heart rate; FS, fractional shortening; Vcf, velocity of circumferential fiber shortening; HW, heart weight; LV, left ventricle; RV, right ventricle; LA, left atrium; RA, right atrium. 

*P , 0.005. 

^†P < 0.00005 −/− compared to +/+, Student’s t test.