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CD4-dependent cell–cell fusion with the orphan receptors GPR1, GPR15, and STRL33. Effector cells expressing the indicated env proteins were mixed with cells expressing combinations of CD4 and GPR1, GPR15, or STRL33. The extent of cell–cell fusion was determined 8 h after cell mixing by measuring luciferase activity as in Fig. 2. Values represent the mean of two or three independent experiments.
