Table 3.
Differential CIMP and CDH1 Methylation Patterns during Stepwise Gastrocarcinogenesis and Their Correlation with Patients' Personal Parameters.
| Parameters | No. | CIMP | P |
CDH1* Methylation (%) |
P | ||
| H (%) | L (%) | N (%) | |||||
| Gender | |||||||
| Male | 34 | 16 (47.1) | 13 (38.2) | 5 (14.7) | .317 | 16 (47.1) | .108 |
| Female | 13 | 8 (61.5) | 5 (38.5) | 0 (0) | 7 (53.8) | ||
| Age (years) | |||||||
| < 50 | 12 | 4 (33.4) | 7 (58.3) | 1 (8.3) | .154 | 2 (16.7) | .010 |
| ≥ 50 | 35 | 20 (57.2) | 11 (31.4) | 4 (11.4) | 21 (60) | ||
| Histology | |||||||
| Noncancerous | 16 | 0 (0) | 12 (75) | 4 (25) | .001 | 4 (25) | .031 |
| Premalignant | 21 | 5 (23.8) | 15 (71.4) | 1 (4.8) | 5 (23.8) | ||
| Cancer | 47 | 24 (51.1) | 18 (38.3) | 5 (10.6) | 23 (48.9) | ||
| d-GC | 27 | 16 (59.3) | 8 (29.6) | 3 (11.1) | .282 | 16 (59.3) | .100 |
| i-GC | 20 | 8 (40) | 10 (50) | 2 (10) | 7 (35) | ||
| Differentiation | |||||||
| Poor | 32 | 16 (50) | 13 (40.6) | 3 (9.4) | .236 | 19 (59.4) | .335 |
| Well | 7 | 4 (57.1) | 2 (28.6) | 1 (14.3) | 2 (28.6) | ||
| Lymph node metastasis |
|||||||
| + | 30 | 15 (50) | 11 (36.7) | 4 (13.3) | .435 | 19 (63.3) | .028 |
| - | 10 | 5 (50) | 5 (50) | 0 (0) | 2 (20) | ||
| H. pylori infection | |||||||
| + | 8 | 3 (37.5) | 3 (37.5) | 2 (25) | .079 | 3 (37.5) | .112 |
| - | 5 | 5 (100) | 0 (0) | 0 (0) | 4 (80) | ||
*
Significant difference of CDH1 methylation incidences between CIMP-H and CIMP-L/N groups (Spearman relative analysis, P = .000).