Table 1.

Reactions of amine nucleophiles with 5-chloro-2,4,6-trifluoropyrimidine (1).

R1R2NH	Products (isolated yield)a		Ratio 3 : 4 b
NH3	3a, 57%	4a	9 : 1
EtNH2	3b, 57%	4b	8 : 1
	3c, 47%	4c	5 : 1
	3d, 41 %	4d	5 : 1
	3e, 49%	4e	3 : 1
	3f, 49%	4f	3 : 1

^a Isolated yield of major products 3. Minor products 4 were not isolated.

^b Ratio of 3 : 4 in crude product mixture by ¹⁹F NMR analysis.