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. 1997 Dec 23;94(26):14804–14808. doi: 10.1073/pnas.94.26.14804

Figure 4.

Figure 4

Increase in RNA granule density due to NT-3 treatment is dose dependent and blocked by a trk inhibitor. (a) Number of SYTO 14-labeled RNA granules per 40 μm of nonaxonal neurite in 4-day-old cortical cultures after 1 h of treatment with varying concentrations of NT-3 (n = 50); (b) Similar measurements in cells treated with 0.01% dimethyl sulfoxide (control), 1 h of 30 nM K252a; 1 h of pretreatment with 30 nM K252a then 1 h of 30 nM K252a and 50 ng/ml NT-3; and 1 h of 50 ng/ml NT-3 (n = 50 all lanes). Treatment with K252a blocked the effect of NT-3 (P < 0.001).