Table 2.

Effects of OFQ on forced motor performance and spontaneous locomotion in rats

	Artificial CSF	0.3 nmol OFQ	1 nmol OFQ
Forced motor performance
Traction test, scores	2.71  ±  0.16	2.75  ±  0.17  NS	2.50  ±  0.17  NS
Grip strength, grams	784.0  ±  58.9	706.2  ±  105.8 NS	760.7  ±  50.9 NS
Spontaneous locomotion
Total distance, cm	1581  ±  171	1624  ±  161 NS	1457  ±  162 NS
Vertical time, s	57.6  ±  6.8	55.6  ±  6.2 NS	39.4  ±  4.1 NS

Motor performance and locomotion were measured in horizontal wire traction and forelimb grip strength procedures followed by a measure of spontaneous exploratory behavior recorded in automated activity monitors as described. Data are given as mean ± SEM. Same drug treatment and statistics as in Fig. 1B. NS, not significant.