Table 1.

Effect of protein kinase modulators on striatal NMDA-induced currents

Compound	I/Ic*	n	P†
Control (9 min)	0.92  ±  0.02	3	—
Control (13 min)	0.92  ±  0.04	3	—
Control (14 min)	0.91  ±  0.01	4	—
PMA (10 nM)§	2.64  ±  0.33	6	≤0.01
PMA (10 nM; −25 mV)§	2.40  ±  0.12	4	≤0.001
4-α-PMA (10 nM)§	1.07  ±  0.04	4	NS
Forskolin (50 μM)‡	1.45  ±  0.03	4	≤0.001
Forskolin (50 μM; −25 mV)‡	1.50  ±  0.10	4	≤0.01
1,9-Dideoxyforskolin (50 μM)‡	0.93  ±  0.04	3	NS
8-Br-cAMP (10 mM)¶	1.86  ±  0.13	7	≤0.001

Experiments were performed at a holding potential of −80 mV unless indicated otherwise. 

^*The relative current amplitude is determined by the ratio (I/Ic) of steady-state responses to 100 μM NMDA and 10 μM glycine after (I) and before (Ic) drug treatment. With the exception of 8-Br-cAMP, which was applied for 10 min, all drugs were applied for 1 min. Results are mean ± SEM. 

^†P values of Student’s t test obtained by comparing drug-treated oocytes with nontreated control oocytes. For comparisons controls recorded at 9 min ( 

^‡), 13 min ( 

^§), and 14 min ( 

^¶) were taken. NS, not significant.