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. 1997 Dec 23;94(26):14865–14870. doi: 10.1073/pnas.94.26.14865

Figure 3.

Figure 3

Effects of intraperitoneal PREG S injection on the performance of impaired aged rats in the Y-maze. (A) Male rats, 23 months old (n = 30) were tested for their memory performance in the Y-maze (ITI = 6 h). The parameter measured was the number of visits in novel arm (%). The horizontal bar represents the median of the distribution. Rats were divided in two groups: impaired rats ( Created by potrace 1.16, written by Peter Selinger 2001-2019 ) (n = 15), whose score was below the median value; unimpaired rats (○) (n = 15), whose score was above median. The mean value of the impaired group did not differ from chance level (t = 1.0, df = 14, ns), while the mean value of the unimpaired group differed from chance level (t = 6.0, df = 14, ns). (B) The impaired animals (n = 15) were split into two subgroups. Vehicle injection had no effect on the performances of impaired rats (n = 8) in the Y-maze (ITI = 6 h). In contrast, the subgroup treated with PREG S (n = 7) performed significantly above chance level 7 h postinjection (t = 5.5, df = 6; ∗, P < 0.02), but returned to chance level 10 days later (t = 2.0, df = 6, ns).