Table 1.
Anti-HIV Activities of Triterpene Derivatives Against HIV-1 Strains in H9 Lymphocytes and MT-4 Cells
| compound | HIV-1IIIB in H9 lymphocytes |
NL4−3 in MT-4 cells |
||||
|---|---|---|---|---|---|---|
| IC50 (μM) | EC50 (μM) | TI | IC50 (μM) | EC50 (μM) | TI | |
| 8 | >42.8 | 0.007 | >6,250 | >5* | 0.096 | >52 |
| 10 | NT | 12.2 | 0.010 | >1,220 | ||
| 11 | NT | 11 | 0.007 | 1,570 | ||
| 12 | >42.7 | 0.32 | >133 | 20.2 | 8.3 | 2.4 |
| 13 | NS | NS | ||||
| 14 | 28.5 | 0.079 | 360 | 21 | 8.3 | 2.5 |
| 15 | 28.5 | 0.68 | 42 | NS | ||
| 16 | >45.1 | 2.6 | >17.2 | >36.1 | 21.6 | >1.7 |
| 17 | NS | NS | ||||
| 18 | NS | NS | ||||
| 19 | >42.7 | 0.017 | 2,500 | 23.5 | 0.045 | 522 |
| 20 | >42.7 | 0.0156 | 2,735 | 22.5 | 0.0085 | 2,650 |
| 21 | 24.0 | 0.007 | 3,400 | 19.5 | 0.11 | 177.3 |
| 22 | >32.6 | 9.3 | >3.5 | NS | ||
*
The highest concentration tested for 8 was 5 μM; there was no observable cytotoxicity at this concentration. NT, not tested in this assay. NS, no suppression.