Figure 3.

The graded steroid infusion resulted in an initial decrease in serum LH levels at 24 h followed by a marked increase that was already apparent by 72 h (top panel). LH is expressed in international units per liter as equivalents of the Second International Reference Preparation of human menopausal gonadotropins. Inhibition of LH was associated with a decrease in normalized glucose uptake at the hypothalamus (middle panel), whereas the increase in LH was associated with a marked increase in normalized uptake at the pituitary (bottom panel) in the absence of a significant hypothalamic effect. One sem is indicated. *, P < 0.02; **, P < 0.001.