Table 1. Survival times of macaques inoculated intracerebrally with brain homogenates from cattle with BASE or BSE, and from humans with vCJD.
Strain | Source | Dose* | Survival time (months) |
BASE | cattle | 25 mg | 26 |
BSE | cattle | 100 mg | 40 |
BSE | cattle | 100 mg | 40 |
vCJD | human | 40 mg | 25 |
vCJD | human | 40 mg | 30 |
vCJD | human | 40 mg | 32 |
vCJD | human | 40 mg | 37 |
Amount of crude brain in 10% brain suspension inoculated intracerebrally. BSE brain had a 10-fold greater concentration of PrPres than the BASE brain). Animals inoculated with vCJD also received the equivalent of 8 mg of brain by intra-tonsillar injection.