Table 1.

ΔTm to polydA.polydT, DNA binding constants to AATT site, and biological activity of derivatives that modified from DB75

Compound	ΔTma	K1 (106)	T.b.ra IC50 nM
Pentamidine	12.6	0.13	2.2
DB75	25	13.5	3.2
DB244	27	60b	60.4
DB555	12.2	1.5c	46.0
DB690	17.1	9.5	1.7
DB351	25	9.4	3.0
DB820	19.3	11.1	6.5
DB991	7.3	0.99	40.7
DB867	22.6	9.4	21
DB829	15.5	2.3	18.7
DB994	18.5	3.5	7.0
DB879	3.6	< 0.1	147

^aFrom ref [31, 43]

^bFrom ref [52] and recalculated for 100mM Na⁺

^cFrom ref [57]