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. 2008 Jun 3;112(4):1453–1460. doi: 10.1182/blood-2007-07-099267

Figure 6.

Figure 6

CYBB, CYBA, NCF-1, and NCF-2 gene expression in EBV-transformed B-cell lines. Cell lines were derived as follows: lane 1, healthy donor; lane 2, X-linked CGD; lane 3, A22-CGD; lane 4, A47-CGD; lane 5, A67-CGD; lane 6, EDA-ID IκB S32I; lane 7, EDA-ID NEMO/IKKγ W420X. (A) CYBB gene expression in EDA-ID cells was significantly lower than that in the normal cell line or other CGD cell lines (P < .05, n = 4, Mann-Whitney test) and equivalent to that in the X-linked CGD cell line. (B) CYBA gene expression was only affected in the A22 CGD cell line (P < .05, n = 4, Mann-Whitney test). (C) NCF-1 gene expression by EDA-ID IκB S32I was significantly lower than that in the normal cell line or other CGD cell lines (P < .05, n = 4, Mann-Whitney test) and equivalent to that in the A47 CGD cell line. (D) NCF-2 gene expression was only partially affected in the EDA-ID IκB S32I cell line (P > .05, n = 4, Mann-Whitney test) but almost abolished in the A67 CGD cell line (P < .05, n = 4, Mann-Whitney test).