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A model of a high DNA-binding activity of tetrameric AML1-ETO to duplicated AML1-binding sites. Runt homology DNA-binding domain (Runt), 4 Nervy homology regions (NHR1-4), and N-terminus (N) of AML1-ETO are marked. The oligomerization provides an advantage to AML1-ETO to duplicated binding sites (TGT/CGGTspaceTGT/CGGT) compared with AML1.
