Table 1.
Consensus AML1 DNA-binding sites, TGCGGT (1) and TGTGGT (2), in the selected DNA sequences
| AML1 (A) | AML1-ETO (AE) | AML1-ETOtr (AEtr) | N-terminal AML1* | |
|---|---|---|---|---|
| (1) × 1 time | 20 | 9 | 7 | 13 |
| (2) × 1 time | 7 | 3 | 0 | 13 |
| (1) × 2-3 times | 14 | 25 | 33 | 0 |
| (2) × 2-3 times | 0 | 0 | 1 | 5 |
| (1) and (2) mixed | 14 | 17 | 9 | 1 |
| No site | 9 | 3 | 0 | 6 |
| No. of total clones | 64 | 57 | 50 | 38 |
| 1 site, % | 49 | 22 | 14 | 81 |
| 2-3 sites,† % | 51 | 78 | 86 | 19 |
*
The result of N-terminal AML1 is from Meyers et al.7
†
By Fisher exact test, the difference between AML1/N-terminal AML1 and AML1-ETO/ AML1-ETOtr is statistically significant (P = .001).