Table 3.

Summary of consistent amino acid change among the five DENV-2 genotype viruses.

PROTEIN				AMINO ACID POSITIONSA
			DOMAIN	MTase					RdRp								Helicase †
NS5				026	155	179	192		748	762	784	799	810	818	835	864
NS3																	187	249	250
STRAIN/YEAR	ACCESSION GENBANK	DIAGNOSIS	GENOTYPE
Tonga/74	AY744147	DF	AMERICAN	I	V	V	R		R	S	S	S	T	L	I	T	R	R	A
S1 vaccine/USA/93	M19197	NA	AMERICAN	I	V	V	R		R	S	S	S	T	L	I	T	R	R	A
131/MEX/92	AF100469	DF	AMERICAN	I	V	V	R		R	S	S	S	T	L	I	T	R	R	A
Ven2/87	AF100465	DF	AMERICAN	I	V	V	R		R	S	S	S	T	L	I	T	R	R	A
I348600/COL/86	AY702040	DF	AMERICAN	I	V	V	R		R	S	S	S	T	L	I	T	R	R	A
OAX/MEX/S707/05§	EF595821	DF	ASIAN/AMERICAN	-	-	-	-		K	T	P	K	A	Q	V	T	K	K	T
OAX/MEXS1038/05§	EF595817/EF595825	DF	ASIAN/AMERICAN	V	I	I	K		K	T	P	K	A	Q	V	T	K	K	T
OAX/MEXS1656/05§	EF595815/EF595820	DF	ASIAN/AMERICAN	V	I	I	K		K	T	P	K	A	Q	V	T	K	K	T
OAX/MEXS739/05§	EF595818/EF595822	DF	ASIAN/AMERICAN	V	I	I	K		K	T	P	K	A	Q	V	T	K	K	T
OAX/MEXS1020/06§	EF595816/EF595824	DHF	ASIAN/AMERICAN	V	I	I	K		K	T	P	K	A	Q	V	T	K	K	T
OAX/MEXS1733/06§	EF595819/EF595823	DF	ASIAN/AMERICAN	V	I	I	K		K	T	P	K	A	Q	V	T	K	K	T
VER/MEX024A/06§	EU570975/EU570983	DHF	ASIAN/AMERICAN	V	I	I	K		K	T	P	K	A	Q	V	T	-	-	-
VER/MEX013A/06§	EU570980/EU570982	DHF	ASIAN/AMERICAN	V	I	I	K		K	T	P	K	A	Q	V	T	-	-	-
Cuba13/97	AY702034	DF	ASIAN/AMERICAN	I	I	I	K		K	T	S	K	A	Q	V	T	K	R	A
Cuba115/97	AY702036	DF	ASIAN/AMERICAN	I	I	I	K		K	T	S	K	A	Q	V	T	K	R	A
Cuba205/97	AY702039	DSS	ASIAN/AMERICAN	I	I	I	K		K	T	S	K	A	Q	V	T	K	R	A
Cuba165/97	AY702038	DHF	ASIAN/AMERICAN	I	I	I	K		K	T	S	K	A	Q	V	T	K	R	A
Cuba58/97	AY702035	DF	ASIAN/AMERICAN	I	I	I	K		K	T	S	K	A	Q	V	T	K	R	A
Cuba89/97	AY702037	DHF/DSS	ASIAN/AMERICAN	I	I	I	K		K	T	S	K	A	Q	V	T	K	R	A
MART/98-703/98	AF208496	DF	ASIAN/AMERICAN	I	I	I	K		K	T	S	K	A	Q	V	T	K	R	A
DR23/01	AB122020	DF	ASIAN/AMERICAN	I	I	I	K		K	T	S	K	A	Q	V	T	K	R	A
DR31/01	AB122021	DF	ASIAN/AMERICAN	I	I	I	K		K	T	S	K	A	Q	V	T	K	R	A
DR59/01	AB122022	DHF	ASIAN/AMERICAN	I	I	I	K		K	T	S	K	A	Q	V	T	K	R	A
BR64022/02	AF489932	NA	ASIAN/AMERICAN	I	I	I	K		K	T	S	K	A	Q	V	T	K	R	A
Mara 4&/Ven/90	AF100466	DHF	ASIAN/AMERICAN	I	I	I	K		K	T	S	K	A	Q	I	T	K	R	A
Jamaica/N.1409/83	M20558	NA	ASIAN/AMERICAN	I	I	I	K		K	T	S	K	A	Q	V	T	K	R	A
China 04/85	AF119661	DHF	ASIAN/AMERICAN	I	I	I	K		K	S	S	K	T	Q	V	T	K	R	T
Bangkok 1974	AJ487271	NA	ASIAN 1	I	V	I	K		R	T	S	K	T	Q	I	A	R	R	A
CO390/Th/99	AF100462	DHF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
16681/USA/97	U87411	NA	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
PDK53/USA/97	U87412	NA	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
16681-PDK53/97	U87411	DHF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH-p11/93	AF022437	DF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH-p12/93	AF022438	DF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH-p14/93	AF022439	DHF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH-7/93	AF022434	DSS	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH-28/93	AF022435	DHF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH-52/93	AF022436	DHF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH-p16/93	AF022440	DF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH-p36/93	AF022441	DHF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH29/93	AF169678	DHF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH36/93	AF169679	DF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH45/93	AF169680	DHF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH55/93	AF169681	DHF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH54/93	AF169682	DHF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH62/93	AF169683	DHF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH63/93	AF169684	DHF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH69/93	AF169685	DHF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH73/93	AF169686	DHF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH76/93	AF169687	DHF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
ThNH81/93	AF169688	DHF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
K0008/Th/99	AF100459	DHF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
K0010/Th/99	AF100460	DF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
C0371/Th/99	AF100461	DF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
C0166/Th/99	AF100463	DF	ASIAN 1	I	V	I	K		R	S	S	K	T	Q	I	A	R	R	A
New Guinea C/44	D00346	DHF	ASIAN 2	I	V	I	K		R	S	S	K	T	Q	I	T	R	R	A
43/China/89	AF204178	DF	ASIAN 2	I	V	I	K		R	S	S	K	T	Q	I	T	R	R	A
44/China/87	AF204177	DF	ASIAN 2	I	V	I	K		R	S	S	K	T	Q	I	T	R	R	A
BA05i/Indon/05	AY858035	DF	COSMOPOLITAN	I	V	I	K		R	S	S	T	T	Q	I	T	K	R	A
TSV01/Austra/93	AY037116	NA	COSMOPOLITAN	I	V	I	K		R	S	S	T	T	Q	I	T	K	R	A
98900666/Indo/04	AB189124	DSS	COSMOPOLITAN	I	V	I	K		R	S	S	T	T	Q	I	T	K	R	A
FJ-10/China/00	AF276619	NA	COSMOPOLITAN	I	V	I	K		R	S	S	R	T	Q	I	T	K	R	A

^&Amino acid sequence was numbered starting from protein NS5 or NS3 to the end of the last codon sequenced.

*Recombinant strain [16].

^†NS3 Accession number for Oaxaca isolates: EF591287–EF591293.

^§Accession numbers for SAM/RdRp Domains