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. Author manuscript; available in PMC: 2009 Jun 21.
Published in final edited form as: J Theor Biol. 2008 Feb 16;252(4):633–648. doi: 10.1016/j.jtbi.2008.01.032

Figure 1. Comparison of the EBV Biological Model and the Computational Model.

Figure 1

EBV co-opts normal B-cell biology to drive infected B-cells into the resting memory state in the peripheral circulation where they are not subject to immunosurveillance. Upon return to Waldeyer’s ring, they may become lytic cells actively producing infectious virus that can either infect new B cells or be shed into saliva to infect new hosts. The activated blast state (subsumed under BLat) and the lytic state (BLyt) are removed by CTLs (TLat and TLyt) and free virus (Vir) cleared by neutralizing antibody [2, 3, 74]. Reproduced from [55] with permission.